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TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

TNF activates three distinct intracellular signaling cascades leading to cell survival, caspase-8–mediated apoptosis, or receptor interacting protein kinase 3 (RIPK3)–dependent necrosis, also called necroptosis. Depending on the cellular context, one of these pathways is activated upon TNF challenge...

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Detalles Bibliográficos
Autores principales:	Morioka, Sho, Broglie, Peter, Omori, Emily, Ikeda, Yuka, Takaesu, Giichi, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926964/ https://www.ncbi.nlm.nih.gov/pubmed/24535827 http://dx.doi.org/10.1083/jcb.201305070

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