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Genotoxic mixtures and dissimilar action: concepts for prediction and assessment

Combinations of genotoxic agents have frequently been assessed without clear assumptions regarding their expected (additive) mixture effects, often leading to claims of synergisms that might in fact be compatible with additivity. We have shown earlier that the combined effects of chemicals, which in...

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Detalles Bibliográficos
Autores principales: Ermler, Sibylle, Scholze, Martin, Kortenkamp, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927065/
https://www.ncbi.nlm.nih.gov/pubmed/24297155
http://dx.doi.org/10.1007/s00204-013-1170-x