Shaping suvorexant: application of experimental and theoretical methods for driving synthetic designs

Dual Orexin Receptor Antagonists (DORA) bind to both the Orexin 1 and 2 receptors. High resolution crystal structures of the Orexin 1 and 2 receptors, both class A GPCRs, were not available at the time of this study, and thus, ligand-based analyses were invoked and successfully applied to the design...

Descripción completa

Detalles Bibliográficos
Autores principales: McGaughey, Georgia, Bayly, Christopher I., Cox, Christopher D., Schreier, John D., Breslin, Michael J., Bogusky, Michael, Pitzenberger, Steve, Ball, Richard, Coleman, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927067/
https://www.ncbi.nlm.nih.gov/pubmed/24488306
http://dx.doi.org/10.1007/s10822-014-9710-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927067/
https://www.ncbi.nlm.nih.gov/pubmed/24488306
http://dx.doi.org/10.1007/s10822-014-9710-x

Ejemplares similares