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Subcellular glucose exposure biases the spatial distribution of insulin granules in single pancreatic beta cells
In living tissues, a cell is exposed to chemical substances delivered partially to its surface. Such a heterogeneous chemical environment potentially induces cell polarity. To evaluate this effect, we developed a microfluidic device that realizes spatially confined delivery of chemical substances at...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927211/ https://www.ncbi.nlm.nih.gov/pubmed/24535122 http://dx.doi.org/10.1038/srep04123 |