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Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction
[Image: see text] An efficient, two-step construction of highly complex alkaloid-like compounds from the natural product fumagillol is described. This approach, which mimics a biosynthetic cyclase/oxidase sequence, allows for rapid and efficient structure elaboration of the basic fumagillol scaffold...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927640/ https://www.ncbi.nlm.nih.gov/pubmed/24410175 http://dx.doi.org/10.1021/ol4035269 |