Diminishing return for increased Mappability with longer sequencing reads: implications of the k-mer distributions in the human genome

BACKGROUND: The amount of non-unique sequence (non-singletons) in a genome directly affects the difficulty of read alignment to a reference assembly for high throughput-sequencing data. Although a longer read is more likely to be uniquely mapped to the reference genome, a quantitative analysis of th...

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Detalles Bibliográficos
Autores principales: Li, Wentian, Freudenberg, Jan, Miramontes, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927684/
https://www.ncbi.nlm.nih.gov/pubmed/24386976
http://dx.doi.org/10.1186/1471-2105-15-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927684/
https://www.ncbi.nlm.nih.gov/pubmed/24386976
http://dx.doi.org/10.1186/1471-2105-15-2

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