Confirmation of warfarin resistance of naturally occurring VKORC1 variants by coexpression with coagulation factor IX and in silico protein modelling

BACKGROUND: VKORC1 has been identified some years ago as the gene encoding vitamin K epoxide reductase (VKOR) – the target protein for coumarin derivates like warfarin or phenprocoumon. Resistance against warfarin and other coumarin-type anticoagulants has been frequently reported over the last 50 y...

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Detalles Bibliográficos
Autores principales: Müller, Elisabeth, Keller, Alexander, Fregin, Andreas, Müller, Clemens R, Rost, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927768/
https://www.ncbi.nlm.nih.gov/pubmed/24491178
http://dx.doi.org/10.1186/1471-2156-15-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927768/
https://www.ncbi.nlm.nih.gov/pubmed/24491178
http://dx.doi.org/10.1186/1471-2156-15-17

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