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The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation
It is believed that the stability and activity of client proteins are passively regulated by the Hsp90 (heat-shock protein 90) chaperone machinery, which is known to be modulated by its intrinsic ATPase activity, co-chaperones and post-translational modifications. However, it is unclear whether clie...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927929/ https://www.ncbi.nlm.nih.gov/pubmed/24117238 http://dx.doi.org/10.1042/BJ20130963 |