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The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation

It is believed that the stability and activity of client proteins are passively regulated by the Hsp90 (heat-shock protein 90) chaperone machinery, which is known to be modulated by its intrinsic ATPase activity, co-chaperones and post-translational modifications. However, it is unclear whether clie...

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Detalles Bibliográficos
Autores principales: Lu, Xin-an, Wang, Xiaofeng, Zhuo, Wei, Jia, Lin, Jiang, Yushan, Fu, Yan, Luo, Yongzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927929/
https://www.ncbi.nlm.nih.gov/pubmed/24117238
http://dx.doi.org/10.1042/BJ20130963

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