Cargando…

Indirubin-3′-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration

AIMS: The small molecule indirubin-3′-monoxime (I3MO) has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation and neointima formation in vivo. The influence of I3MO on VSMC migration and vascular inflammation, two additional key players during the onset of atherosclerosis and rest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blažević, Tina, Schaible, Anja M., Weinhäupl, Katharina, Schachner, Daniel, Nikels, Felix, Weinigel, Christina, Barz, Dagmar, Atanasov, Atanas G., Pergola, Carlo, Werz, Oliver, Dirsch, Verena M., Heiss, Elke H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928003/ https://www.ncbi.nlm.nih.gov/pubmed/24368834 http://dx.doi.org/10.1093/cvr/cvt339

Ejemplares similares

Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3′-monoxime
por: Heiss, Elke H., et al.
Publicado: (2016)

Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases
por: Blažević, Tina, et al.
Publicado: (2015)

An Indirubin Derivative, Indirubin-3′-Monoxime Suppresses Oral Cancer Tumorigenesis through the Downregulation of Survivin
por: Lo, Wan-Yu, et al.
Publicado: (2013)

Synthesis and antibacterial activity studies in vitro of indirubin-3′-monoximes
por: Yang, Fen-Fen, et al.
Publicado: (2022)

12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of Transcription 3
por: Blažević, Tina, et al.
Publicado: (2013)

Resveratrol inhibits migration and Rac1 activation in EGF- but not PDGF-activated vascular smooth muscle cells
por: Kumerz, Mario, et al.
Publicado: (2011)

Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma
por: Yu, Zhen, et al.
Publicado: (2022)

Indirubin-3′-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperphosphorylation
por: Zhang, Shu-gang, et al.
Publicado: (2016)

Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo
por: Liu, Rongxia, et al.
Publicado: (2017)

Capsaicin from chili ( Capsicum spp.) inhibits vascular smooth muscle cell proliferation
por: Liu, Rongxia, et al.
Publicado: (2015)

A Sensitive LC-MS/MS Method for the Simultaneous Determination of Two Thia-Analogous Indirubin N-Glycosides and Indirubin-3′-Monoxime in Plasma and Cell Culture Medium
por: Fischle, Alica, et al.
Publicado: (2022)

Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner
por: Schreiner, Cornelia E., et al.
Publicado: (2011)

Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice
por: Medina-Moreno, Sandra, et al.
Publicado: (2017)

Inhibition of growth factor mediated Akt phosphorylation in vascular smooth muscle cells by resveratrol: the contribution of SH2 domain containing phosphatase 2 and reactive oxygen species
por: Schreiner, Cornelia E, et al.
Publicado: (2008)

Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
por: Heiss, Elke H., et al.
Publicado: (2014)

P810: A NOVEL INDIRUBIN-3-MONOXIME DERIVATIVES FUNCTION AS DISRUPTORS OF PROTEOSTASIS VIA TARGETING TRIM28 IN MULTIPLE MYELOMA
por: Fang, Teng, et al.
Publicado: (2023)

Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation
por: Waltenberger, Birgit, et al.
Publicado: (2015)

Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation
por: Heiss, Elke H, et al.
Publicado: (2016)

Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status
por: Ladurner, Angela, et al.
Publicado: (2012)

Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level
por: Malainer, Clemens, et al.
Publicado: (2017)

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation
por: Liu, Rongxia, et al.
Publicado: (2015)

Cultured rat aortic vascular smooth muscle cells do not express a functional TRPV1
por: Blažević, Tina, et al.
Publicado: (2023)

Short Chain (≤C4) Esterification Increases Bioavailability of Rosmarinic Acid and Its Potency to Inhibit Vascular Smooth Muscle Cell Proliferation
por: Blažević, Tina, et al.
Publicado: (2021)

Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response
por: Zimmermann, Kristin, et al.
Publicado: (2015)

Interference with platelet-derived growth factor-induced signalling in vascular smooth muscle cells by roscovitine
por: Sroka, Irene, et al.
Publicado: (2008)

Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux
por: Wang, Limei, et al.
Publicado: (2018)

Identification of Ostruthin from Peucedanum ostruthium Rhizomes as an Inhibitor of Vascular Smooth Muscle Cell Proliferation
por: Joa, Helge, et al.
Publicado: (2011)

Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages
por: Wang, Limei, et al.
Publicado: (2017)

Indirubin exerts anticancer effects on human glioma cells by inducing apoptosis and autophagy
por: Li, Zhaohui, et al.
Publicado: (2020)

Glucose availability is a decisive factor for Nrf2-mediated gene expression()
por: Heiss, Elke H., et al.
Publicado: (2013)

p53-Mediated Oxidative Stress Enhances Indirubin-3′-Monoxime-Induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-Related Apoptosis-Inducing Ligand Expression
por: Dilshara, Matharage Gayani, et al.
Publicado: (2019)

Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages
por: Wang, Limei, et al.
Publicado: (2015)

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy
por: Pergola, Carlo, et al.
Publicado: (2017)

Viability and infectivity of Toxoplasma gondii tachyzoites exposed to Butanedione monoxime
por: Bajelan, Sara, et al.
Publicado: (2020)

Colorimetric determination of urea using diacetyl monoxime with strong acids
por: Langenfeld, Noah James, et al.
Publicado: (2021)

NF-κB Inhibitors from Eurycoma longifolia
por: Tran, Thi Van Anh, et al.
Publicado: (2014)

2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells
por: Ladurner, Angela, et al.
Publicado: (2012)

6‐Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP‐1‐Derived Macrophages
por: Wang, Dongdong, et al.
Publicado: (2018)

Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: Assessing the activity of flavonoids from the stem bark of Oroxylum indicum
por: Tran, Thi Van Anh, et al.
Publicado: (2015)

The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability
por: Wang, Limei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_n3ki6s0vbpedrva5kvjuiuqhi4