Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia

Pseudoachondroplasia (PSACH) is an autosomal dominant skeletal dysplasia caused by mutations in cartilage oligomeric matrix protein (COMP) and characterised by short limbed dwarfism and early onset osteoarthritis. Mouse models of PSACH show variable retention of mutant COMP in the ER of chondrocytes...

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Detalles Bibliográficos
Autores principales: Piróg, Katarzyna A., Irman, Andreja, Young, Siobhan, Halai, Poonam, Bell, Peter A., Boot-Handford, Raymond P., Briggs, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928032/
https://www.ncbi.nlm.nih.gov/pubmed/24558358
http://dx.doi.org/10.1371/journal.pone.0085145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928032/
https://www.ncbi.nlm.nih.gov/pubmed/24558358
http://dx.doi.org/10.1371/journal.pone.0085145

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