A Novel Radiation-Induced p53 Mutation Is Not Implicated in Radiation Resistance via a Dominant-Negative Effect

Understanding the mutations that confer radiation resistance is crucial to developing mechanisms to subvert this resistance. Here we describe the creation of a radiation resistant cell line and characterization of a novel p53 mutation. Treatment with 20 Gy radiation was used to induce mutations in t...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Yunguang, Myers, Carey Jeanne, Dicker, Adam Paul, Lu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928108/
https://www.ncbi.nlm.nih.gov/pubmed/24558369
http://dx.doi.org/10.1371/journal.pone.0087492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928108/
https://www.ncbi.nlm.nih.gov/pubmed/24558369
http://dx.doi.org/10.1371/journal.pone.0087492

Ejemplares similares