The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase

The mechanistic target of rapamycin (mTOR) functions as a component of two large complexes, mTORC1 and mTORC2, which play crucial roles in regulating cell growth and homeostasis. However, the molecular mechanisms by which mTOR controls cell proliferation remain elusive. Here we show that the FoxO3a...

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Detalles Bibliográficos
Autores principales: Mori, Shunsuke, Nada, Shigeyuki, Kimura, Hironobu, Tajima, Shoji, Takahashi, Yusuke, Kitamura, Ayaka, Oneyama, Chitose, Okada, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928304/
https://www.ncbi.nlm.nih.gov/pubmed/24558442
http://dx.doi.org/10.1371/journal.pone.0088891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928304/
https://www.ncbi.nlm.nih.gov/pubmed/24558442
http://dx.doi.org/10.1371/journal.pone.0088891

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