Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle

Oxidative stress is a critical disease modifier in the muscular dystrophies. Recently, we discovered a pathway by which mechanical stretch activates NADPH Oxidase 2 (Nox2) dependent ROS generation (X-ROS). Our work in dystrophic skeletal muscle revealed that X-ROS is excessive in dystrophin-deficien...

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Detalles Bibliográficos
Autores principales: Kombairaju, Ponvijay, Kerr, Jaclyn P., Roche, Joseph A., Pratt, Stephen J. P., Lovering, Richard M., Sussan, Thomas E., Kim, Jung-Hyun, Shi, Guoli, Biswal, Shyam, Ward, Christopher W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928547/
https://www.ncbi.nlm.nih.gov/pubmed/24600403
http://dx.doi.org/10.3389/fphys.2014.00057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928547/
https://www.ncbi.nlm.nih.gov/pubmed/24600403
http://dx.doi.org/10.3389/fphys.2014.00057

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