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Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid
BACKGROUND: Epigenetic modifications, such as cytosine methylation in CpG-rich regions, regulate multiple functions in mammalian development. Maternal nutrients affecting one-carbon metabolism during gestation can exert long-term effects on the health of the progeny. Using C57BL/6 J mice, we investi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928622/ https://www.ncbi.nlm.nih.gov/pubmed/24484737 http://dx.doi.org/10.1186/1756-8935-7-3 |