High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines

Myotonic dystrophy (DM) is a multi-system neuromuscular disorder for which there is no treatment. We have developed a medium throughput phenotypic assay, based on the identification of nuclear foci in DM patient cell lines using in situ hybridization and high-content imaging to screen for potentiall...

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Detalles Bibliográficos
Autores principales: Ketley, Ami, Chen, Catherine Z., Li, Xin, Arya, Sukrat, Robinson, Thelma E., Granados-Riveron, Javier, Udosen, Inyang, Morris, Glenn E., Holt, Ian, Furling, Denis, Chaouch, Soraya, Haworth, Ben, Southall, Noel, Shinn, Paul, Zheng, Wei, Austin, Christopher P., Hayes, Christopher J., Brook, J. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929092/
https://www.ncbi.nlm.nih.gov/pubmed/24179176
http://dx.doi.org/10.1093/hmg/ddt542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929092/
https://www.ncbi.nlm.nih.gov/pubmed/24179176
http://dx.doi.org/10.1093/hmg/ddt542

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