Antibody light chain variable domains and their biophysically improved versions for human immunotherapy

We set out to gain deeper insight into the potential of antibody light chain variable domains (V(L)s) as immunotherapeutics. To this end, we generated a naïve human V(L) phage display library and, by using a method previously shown to select for non-aggregating antibody heavy chain variable domains...

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Detalles Bibliográficos
Autores principales: Kim, Dae Young, To, Rebecca, Kandalaft, Hiba, Ding, Wen, van Faassen, Henk, Luo, Yan, Schrag, Joseph D, St-Amant, Nadereh, Hefford, Mary, Hirama, Tomoko, Kelly, John F, MacKenzie, Roger, Tanha, Jamshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929445/
https://www.ncbi.nlm.nih.gov/pubmed/24423624
http://dx.doi.org/10.4161/mabs.26844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929445/
https://www.ncbi.nlm.nih.gov/pubmed/24423624
http://dx.doi.org/10.4161/mabs.26844

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