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Antibody light chain variable domains and their biophysically improved versions for human immunotherapy
We set out to gain deeper insight into the potential of antibody light chain variable domains (V(L)s) as immunotherapeutics. To this end, we generated a naïve human V(L) phage display library and, by using a method previously shown to select for non-aggregating antibody heavy chain variable domains...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929445/ https://www.ncbi.nlm.nih.gov/pubmed/24423624 http://dx.doi.org/10.4161/mabs.26844 |