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Methods for site-specific drug conjugation to antibodies

Antibody drug conjugates (ADCs) are an emerging class of targeted therapeutics with the potential to improve therapeutic index over traditional chemotherapy. Drugs and linkers have been the current focus of ADC development, in addition to antibody and target selection. Recently, however, the importa...

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Detalles Bibliográficos
Autores principales: Behrens, Christopher R, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929454/
https://www.ncbi.nlm.nih.gov/pubmed/24135651
http://dx.doi.org/10.4161/mabs.26632