SAMHD1 Restricts HIV-1 Replication and Regulates Interferon Production in Mouse Myeloid Cells

SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4(+) T cells and that is counteracted in SIV and HIV-2 by the Vpx accessory protein. The protein is a phosphohydrolase that lowers the concentration of deoxynucleoside triphosphates (dNTP), blocking rever...

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Detalles Bibliográficos
Autores principales: Zhang, Ruonan, Bloch, Nicolin, Nguyen, Laura A., Kim, Baek, Landau, Nathaniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929709/
https://www.ncbi.nlm.nih.gov/pubmed/24586870
http://dx.doi.org/10.1371/journal.pone.0089558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929709/
https://www.ncbi.nlm.nih.gov/pubmed/24586870
http://dx.doi.org/10.1371/journal.pone.0089558

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