Cargando…

SAMHD1 Restricts HIV-1 Replication and Regulates Interferon Production in Mouse Myeloid Cells

SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4(+) T cells and that is counteracted in SIV and HIV-2 by the Vpx accessory protein. The protein is a phosphohydrolase that lowers the concentration of deoxynucleoside triphosphates (dNTP), blocking rever...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ruonan, Bloch, Nicolin, Nguyen, Laura A., Kim, Baek, Landau, Nathaniel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929709/ https://www.ncbi.nlm.nih.gov/pubmed/24586870 http://dx.doi.org/10.1371/journal.pone.0089558

Ejemplares similares

Restriction of diverse retroviruses by SAMHD1
por: Gramberg, Thomas, et al.
Publicado: (2013)

TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes
por: Hofmann, Henning, et al.
Publicado: (2016)

Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis
por: An, Ni, et al.
Publicado: (2022)

SAMHD1: a new insight into HIV-1 restriction in myeloid cells
por: St Gelais, Corine, et al.
Publicado: (2011)

Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1
por: Wang, Zhonghua, et al.
Publicado: (2018)

Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction
por: Xie, Maorong, et al.
Publicado: (2019)

DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1
por: Jáuregui, Paula, et al.
Publicado: (2018)

Interferon-α blocks HIV-1 infection in non-dividing myeloid cells despite SAMHD1 degradation and high deoxynucleoside triphosphates supply
por: Dragin, Loic, et al.
Publicado: (2013)

Evidence that HIV-1 restriction factor SAMHD1 facilitates differentiation of myeloid THP-1 cells
por: Dragin, Loic, et al.
Publicado: (2015)

Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells
por: Hollenbaugh, Joseph A., et al.
Publicado: (2013)

Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply
por: Dragin, Loic, et al.
Publicado: (2013)

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages
por: Mahboubi, Bijan, et al.
Publicado: (2018)

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac
por: Brandariz-Nuñez, Alberto, et al.
Publicado: (2012)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
por: Martinat, Charlotte, et al.
Publicado: (2021)

A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages
por: Mlcochova, Petra, et al.
Publicado: (2017)

Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1
por: Brandariz-Nuñez, Alberto, et al.
Publicado: (2013)

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
por: Descours, Benjamin, et al.
Publicado: (2012)

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
por: Tsai, Ming-Han C., et al.
Publicado: (2023)

SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells
por: Ordonez, Paula, et al.
Publicado: (2017)

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4(+) T-lymphocytes cannot be upregulated by interferons
por: St Gelais, Corine, et al.
Publicado: (2012)

SAMHD1: a new contributor to HIV-1 restriction in resting CD4(+) T-cells
por: Wu, Li
Publicado: (2012)

Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle
por: Sommer, Andreas F. R., et al.
Publicado: (2016)

SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition
por: Szaniawski, Matthew A., et al.
Publicado: (2018)

Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway
por: Ren, Huiling, et al.
Publicado: (2020)

Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
por: Plitnik, Timothy, et al.
Publicado: (2018)

Samhd1 knockout mice: modeling retrovirus restriction in vivo
por: Wu, Li
Publicado: (2013)

Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1
por: Wu, Li
Publicado: (2013)

Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts
por: Mereby, Sarah A., et al.
Publicado: (2018)

A Continuous Enzyme-Coupled Assay for Triphosphohydrolase Activity of HIV-1 Restriction Factor SAMHD1
por: Arnold, Laurence H., et al.
Publicado: (2014)

Substrates and Inhibitors of SAMHD1
por: Hollenbaugh, Joseph A., et al.
Publicado: (2017)

HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis
por: Mohamed, Ahlam, et al.
Publicado: (2021)

SAMHD1 Functions and Human Diseases
por: Coggins, Si’Ana A., et al.
Publicado: (2020)

Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis
por: Bowen, Nicole E., et al.
Publicado: (2022)

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1
por: Maelfait, Jonathan, et al.
Publicado: (2016)

SAMHD1 specifically restricts retroviruses through its RNase activity
por: Choi, Jongsu, et al.
Publicado: (2015)

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction
por: Arnold, Laurence H., et al.
Publicado: (2015)

Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection
por: Fu, Weihui, et al.
Publicado: (2016)

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
por: Schott, Kerstin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jj8q0bc1461rbclo9sv1623f18