Mouse Models for Pseudoxanthoma Elasticum: Genetic and Dietary Modulation of the Ectopic Mineralization Phenotypes

Pseudoxanthoma elasticum (PXE), a heritable ectopic mineralization disorder, is caused by mutations in the ABCC6 gene. Null mice (Abcc6(−/−)) recapitulate the genetic, histopathologic and ultrastructural features of PXE, and they demonstrate early and progressive mineralization of vibrissae dermal s...

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Detalles Bibliográficos
Autores principales: Li, Qiaoli, Guo, Haitao, Chou, David W., Berndt, Annerose, Sundberg, John P., Uitto, Jouni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929712/
https://www.ncbi.nlm.nih.gov/pubmed/24586646
http://dx.doi.org/10.1371/journal.pone.0089268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929712/
https://www.ncbi.nlm.nih.gov/pubmed/24586646
http://dx.doi.org/10.1371/journal.pone.0089268

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