V3-Independent Competitive Resistance of a Dual-X4 HIV-1 to the CXCR4 Inhibitor AMD3100

A CXCR4 inhibitor-resistant HIV-1 was isolated from a dual-X4 HIV-1 in vitro. The resistant variant displayed competitive resistance to the CXCR4 inhibitor AMD3100, indicating that the resistant variant had a higher affinity for CXCR4 than that of the wild-type HIV-1. Amino acid sequence analyses re...

Descripción completa

Detalles Bibliográficos
Autores principales: Maeda, Yosuke, Terasawa, Hiromi, Nakano, Yusuke, Monde, Kazuaki, Yusa, Keisuke, Oka, Shinichi, Takiguchi, Masafumi, Harada, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929750/
https://www.ncbi.nlm.nih.gov/pubmed/24586840
http://dx.doi.org/10.1371/journal.pone.0089515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929750/
https://www.ncbi.nlm.nih.gov/pubmed/24586840
http://dx.doi.org/10.1371/journal.pone.0089515

Ejemplares similares