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V3-Independent Competitive Resistance of a Dual-X4 HIV-1 to the CXCR4 Inhibitor AMD3100

A CXCR4 inhibitor-resistant HIV-1 was isolated from a dual-X4 HIV-1 in vitro. The resistant variant displayed competitive resistance to the CXCR4 inhibitor AMD3100, indicating that the resistant variant had a higher affinity for CXCR4 than that of the wild-type HIV-1. Amino acid sequence analyses re...

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Detalles Bibliográficos
Autores principales:	Maeda, Yosuke, Terasawa, Hiromi, Nakano, Yusuke, Monde, Kazuaki, Yusa, Keisuke, Oka, Shinichi, Takiguchi, Masafumi, Harada, Shinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929750/ https://www.ncbi.nlm.nih.gov/pubmed/24586840 http://dx.doi.org/10.1371/journal.pone.0089515

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