Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

A bioorthogonal organometallic reaction is a biocompatible transformation undergone by a synthetic material exclusively through the mediation of a non-biotic metal source; a selective process used to label biomolecules and activate probes in biological environs. Here we report the in vitro bioorthog...

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Detalles Bibliográficos
Autores principales: Weiss, Jason T., Dawson, John C., Macleod, Kenneth G., Rybski, Witold, Fraser, Craig, Torres-Sánchez, Carmen, Patton, E. Elizabeth, Bradley, Mark, Carragher, Neil O., Unciti-Broceta, Asier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929780/
https://www.ncbi.nlm.nih.gov/pubmed/24522696
http://dx.doi.org/10.1038/ncomms4277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929780/
https://www.ncbi.nlm.nih.gov/pubmed/24522696
http://dx.doi.org/10.1038/ncomms4277

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