The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A

During DNA damage response, the RING E3 ligase RNF168 ubiquitinates nucleosomal H2A at K13–15. Here we show that the ubiquitination reaction is regulated by its substrate. We define a region on the RING domain important for target recognition and identify the H2A/H2B dimer as the minimal substrate t...

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Detalles Bibliográficos
Autores principales: Mattiroli, Francesca, Uckelmann, Michael, Sahtoe, Danny D., van Dijk, Willem J., Sixma, Titia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929782/
https://www.ncbi.nlm.nih.gov/pubmed/24518117
http://dx.doi.org/10.1038/ncomms4291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929782/
https://www.ncbi.nlm.nih.gov/pubmed/24518117
http://dx.doi.org/10.1038/ncomms4291

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