Identification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemia

The cell of origin and triggering events for leukaemia are mostly unknown. Here we show that the bone marrow contains a progenitor that expresses renin throughout development and possesses a B-lymphocyte pedigree. This cell requires RBP-J to differentiate. Deletion of RBP-J in these renin-expressing...

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Detalles Bibliográficos
Autores principales: Belyea, Brian C., Xu, Fang, Pentz, Ellen S., Medrano, Silvia, Li, Minghong, Hu, Yan, Turner, Stephen, Legallo, Robin, Jones, Craig A., Tario, Joseph D., Liang, Ping, Gross, Kenneth W., Sequeira-Lopez, Maria Luisa S., Gomez, R. Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929784/
https://www.ncbi.nlm.nih.gov/pubmed/24549417
http://dx.doi.org/10.1038/ncomms4273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929784/
https://www.ncbi.nlm.nih.gov/pubmed/24549417
http://dx.doi.org/10.1038/ncomms4273

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