Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Abnormal vascularization of solid tumours results in the development of microenvironments deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed cells. Such cells display enhanced resistance to standard chemotherapeutic agents and repopulate tumours after therapy. He...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaonan, Fryknäs, Mårten, Hernlund, Emma, Fayad, Walid, De Milito, Angelo, Olofsson, Maria Hägg, Gogvadze, Vladimir, Dang, Long, Påhlman, Sven, Schughart, Leoni A. Kunz, Rickardson, Linda, D′Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Larsson, Rolf, Linder, Stig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929804/
https://www.ncbi.nlm.nih.gov/pubmed/24548894
http://dx.doi.org/10.1038/ncomms4295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929804/
https://www.ncbi.nlm.nih.gov/pubmed/24548894
http://dx.doi.org/10.1038/ncomms4295

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