A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson’s disease

Abnormal motor behaviors in Parkinson’s disease (PD) result from striatal dysfunction due to an imbalance between dopamine and glutamate transmissions that are integrated by dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32). c-Abelson tyrosine kinase (c-Abl) phosphorylates cyclin-depe...

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Detalles Bibliográficos
Autores principales: Tanabe, Akie, Yamamura, Yukio, Kasahara, Jiro, Morigaki, Ryoma, Kaji, Ryuji, Goto, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929858/
https://www.ncbi.nlm.nih.gov/pubmed/24600352
http://dx.doi.org/10.3389/fncel.2014.00050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929858/
https://www.ncbi.nlm.nih.gov/pubmed/24600352
http://dx.doi.org/10.3389/fncel.2014.00050

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