Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway

BACKGROUND: Higher frequency of Smad4 inactivation or loss of expression is observed in metastasis of colorectal cancer (CRC) leading to unfavourable survival and contributes to chemoresistance. However, the molecular mechanism of how Smad4 regulates chemosensitivity of CRC is unknown. METHODS: We e...

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Detalles Bibliográficos
Autores principales: Zhang, B, Chen, X, Bae, S, Singh, K, Washington, M K, Datta, P K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929873/
https://www.ncbi.nlm.nih.gov/pubmed/24384683
http://dx.doi.org/10.1038/bjc.2013.789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929873/
https://www.ncbi.nlm.nih.gov/pubmed/24384683
http://dx.doi.org/10.1038/bjc.2013.789

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