Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy

This work describes a first population pharmacokinetic (PK) model for free and total cefazolin during pregnancy, which can be used for dose regimen optimization. Secondly, analysis of PK studies in pregnant patients is challenging due to study design limitations. We therefore developed a semiphysiol...

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Detalles Bibliográficos
Autores principales: van Hasselt, J. G. Coen, Allegaert, Karel, van Calsteren, Kristel, Beijnen, Jos H., Schellens, Jan H. M., Huitema, Alwin D. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930089/
https://www.ncbi.nlm.nih.gov/pubmed/24672799
http://dx.doi.org/10.1155/2014/897216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930089/
https://www.ncbi.nlm.nih.gov/pubmed/24672799
http://dx.doi.org/10.1155/2014/897216

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