Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

Damaged mitochondria can be selectively eliminated by mitophagy. Although two gene products mutated in Parkinson’s disease, PINK1, and Parkin have been found to play a central role in triggering mitophagy in mammals, how the pre-autophagosomal isolation membrane selectively and accurately engulfs da...

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Detalles Bibliográficos
Autores principales: Yamano, Koji, Fogel, Adam I, Wang, Chunxin, van der Bliek, Alexander M, Youle, Richard J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930140/
https://www.ncbi.nlm.nih.gov/pubmed/24569479
http://dx.doi.org/10.7554/eLife.01612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930140/
https://www.ncbi.nlm.nih.gov/pubmed/24569479
http://dx.doi.org/10.7554/eLife.01612

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