The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines

Wnt/β-catenin is a major regulator of stem cell self-renewal and differentiation and this signaling pathway is aberrantly activated in a several cancers, including osteosarcoma (OS). Attenuation of Wnt/β-catenin activity by tankyrase inhibitors is an appealing strategy in treatment of OS. The effica...

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Detalles Bibliográficos
Autores principales: Wessel Stratford, Eva, Daffinrud, Jeanette, Munthe, Else, Castro, Russell, Waaler, Jo, Krauss, Stefan, Myklebost, Ola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd. 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930388/
https://www.ncbi.nlm.nih.gov/pubmed/24403055
http://dx.doi.org/10.1002/cam4.170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930388/
https://www.ncbi.nlm.nih.gov/pubmed/24403055
http://dx.doi.org/10.1002/cam4.170

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