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Does the cis/trans configuration of peptide bonds in bioactive tripeptides play a role in ACE-1 enzyme inhibition?

BACKGROUND: The milk casein-derived bioactive tripeptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP) have been shown to prevent development of hypertension in animal models and to lower blood pressure in moderately hypertensive subjects in most but not all clinical trials. Inh...

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Detalles Bibliográficos
Autores principales: Siltari, Aino, Viitanen, Riikka, Kukkurainen, Sampo, Vapaatalo, Heikki, Valjakka, Jarkko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930482/
https://www.ncbi.nlm.nih.gov/pubmed/24596454
http://dx.doi.org/10.2147/BTT.S54056