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Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism

In metabolism research, thermodynamics is usually used to determine the directionality of a reaction or the feasibility of a pathway. However, the relationship between thermodynamic potentials and fluxes is not limited to questions of directionality: thermodynamics also affects the kinetics of react...

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Detalles Bibliográficos
Autores principales: Noor, Elad, Bar-Even, Arren, Flamholz, Avi, Reznik, Ed, Liebermeister, Wolfram, Milo, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930492/
https://www.ncbi.nlm.nih.gov/pubmed/24586134
http://dx.doi.org/10.1371/journal.pcbi.1003483