Loss of Trabid, a New Negative Regulator of the Drosophila Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span

A relatively unexplored nexus in Drosophila Immune deficiency (IMD) pathway is TGF-beta Activating Kinase 1 (TAK1), which triggers both immunity and apoptosis. In a cell culture screen, we identified that Lysine at position 142 was a K63-linked Ubiquitin acceptor site for TAK1, required for signalli...

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Detalles Bibliográficos
Autores principales: Fernando, Merennege Dilan Anush, Kounatidis, Ilias, Ligoxygakis, Petros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930493/
https://www.ncbi.nlm.nih.gov/pubmed/24586180
http://dx.doi.org/10.1371/journal.pgen.1004117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930493/
https://www.ncbi.nlm.nih.gov/pubmed/24586180
http://dx.doi.org/10.1371/journal.pgen.1004117

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