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k-OptForce: Integrating Kinetics with Flux Balance Analysis for Strain Design
Computational strain design protocols aim at the system-wide identification of intervention strategies for the enhanced production of biochemicals in microorganisms. Existing approaches relying solely on stoichiometry and rudimentary constraint-based regulation overlook the effects of metabolite con...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930495/ https://www.ncbi.nlm.nih.gov/pubmed/24586136 http://dx.doi.org/10.1371/journal.pcbi.1003487 |