HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2

BACKGROUND: HIV proteins Nef and Vpu down-modulate various host factors to evade immune defenses. Indeed, the CD4 receptor is down-regulated by Nef and Vpu, whereas virion-tethering BST2 is depleted by Vpu. Antibody-dependent cell-mediated cytotoxicity (ADCC) is increasingly recognized as a potentia...

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Detalles Bibliográficos
Autores principales: Pham, Tram NQ, Lukhele, Sabelo, Hajjar, Fadi, Routy, Jean-Pierre, Cohen, Éric A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930549/
https://www.ncbi.nlm.nih.gov/pubmed/24498878
http://dx.doi.org/10.1186/1742-4690-11-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930549/
https://www.ncbi.nlm.nih.gov/pubmed/24498878
http://dx.doi.org/10.1186/1742-4690-11-15

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