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HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2

BACKGROUND: HIV proteins Nef and Vpu down-modulate various host factors to evade immune defenses. Indeed, the CD4 receptor is down-regulated by Nef and Vpu, whereas virion-tethering BST2 is depleted by Vpu. Antibody-dependent cell-mediated cytotoxicity (ADCC) is increasingly recognized as a potentia...

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Detalles Bibliográficos
Autores principales:	Pham, Tram NQ, Lukhele, Sabelo, Hajjar, Fadi, Routy, Jean-Pierre, Cohen, Éric A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930549/ https://www.ncbi.nlm.nih.gov/pubmed/24498878 http://dx.doi.org/10.1186/1742-4690-11-15

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