Acute Lymphoid Leukemia Cells with Greater Stem Cell Antigen-1 (Ly6a/Sca-1) Expression Exhibit Higher Levels of Metalloproteinase Activity and Are More Aggressive In Vivo

Stem cell antigen-1 (Ly6a/Sca-1) is a gene that is expressed in activated lymphocytes, hematopoietic stem cells and stem cells of a variety of tissues in mice. Despite decades of study its functions remain poorly defined. These studies explored the impact of expression of this stem cell associated g...

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Autores principales: Hsu, Yu-Chiao, Mildenstein, Kurt, Hunter, Kordell, Tkachenko, Olena, Mullen, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930640/
https://www.ncbi.nlm.nih.gov/pubmed/24586463
http://dx.doi.org/10.1371/journal.pone.0088966
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author Hsu, Yu-Chiao
Mildenstein, Kurt
Hunter, Kordell
Tkachenko, Olena
Mullen, Craig A.
author_facet Hsu, Yu-Chiao
Mildenstein, Kurt
Hunter, Kordell
Tkachenko, Olena
Mullen, Craig A.
author_sort Hsu, Yu-Chiao
collection PubMed
description Stem cell antigen-1 (Ly6a/Sca-1) is a gene that is expressed in activated lymphocytes, hematopoietic stem cells and stem cells of a variety of tissues in mice. Despite decades of study its functions remain poorly defined. These studies explored the impact of expression of this stem cell associated gene in acute lymphoid leukemia. Higher levels of Ly6a/Sca-1 expression led to more aggressive leukemia growth in vivo and earlier death of hosts. Leukemias expressing higher levels of Ly6a/Sca-1 exhibited higher levels of matrix metalloproteinases. The results suggest the hypothesis that the more aggressive behavior of Ly6a/Sca-1 expressing leukemias is due at least in part to greater capacity to degrade microenvironmental stroma and invade tissues.
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spelling pubmed-39306402014-02-25 Acute Lymphoid Leukemia Cells with Greater Stem Cell Antigen-1 (Ly6a/Sca-1) Expression Exhibit Higher Levels of Metalloproteinase Activity and Are More Aggressive In Vivo Hsu, Yu-Chiao Mildenstein, Kurt Hunter, Kordell Tkachenko, Olena Mullen, Craig A. PLoS One Research Article Stem cell antigen-1 (Ly6a/Sca-1) is a gene that is expressed in activated lymphocytes, hematopoietic stem cells and stem cells of a variety of tissues in mice. Despite decades of study its functions remain poorly defined. These studies explored the impact of expression of this stem cell associated gene in acute lymphoid leukemia. Higher levels of Ly6a/Sca-1 expression led to more aggressive leukemia growth in vivo and earlier death of hosts. Leukemias expressing higher levels of Ly6a/Sca-1 exhibited higher levels of matrix metalloproteinases. The results suggest the hypothesis that the more aggressive behavior of Ly6a/Sca-1 expressing leukemias is due at least in part to greater capacity to degrade microenvironmental stroma and invade tissues. Public Library of Science 2014-02-20 /pmc/articles/PMC3930640/ /pubmed/24586463 http://dx.doi.org/10.1371/journal.pone.0088966 Text en © 2014 Hsu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hsu, Yu-Chiao
Mildenstein, Kurt
Hunter, Kordell
Tkachenko, Olena
Mullen, Craig A.
Acute Lymphoid Leukemia Cells with Greater Stem Cell Antigen-1 (Ly6a/Sca-1) Expression Exhibit Higher Levels of Metalloproteinase Activity and Are More Aggressive In Vivo
title Acute Lymphoid Leukemia Cells with Greater Stem Cell Antigen-1 (Ly6a/Sca-1) Expression Exhibit Higher Levels of Metalloproteinase Activity and Are More Aggressive In Vivo
title_full Acute Lymphoid Leukemia Cells with Greater Stem Cell Antigen-1 (Ly6a/Sca-1) Expression Exhibit Higher Levels of Metalloproteinase Activity and Are More Aggressive In Vivo
title_fullStr Acute Lymphoid Leukemia Cells with Greater Stem Cell Antigen-1 (Ly6a/Sca-1) Expression Exhibit Higher Levels of Metalloproteinase Activity and Are More Aggressive In Vivo
title_full_unstemmed Acute Lymphoid Leukemia Cells with Greater Stem Cell Antigen-1 (Ly6a/Sca-1) Expression Exhibit Higher Levels of Metalloproteinase Activity and Are More Aggressive In Vivo
title_short Acute Lymphoid Leukemia Cells with Greater Stem Cell Antigen-1 (Ly6a/Sca-1) Expression Exhibit Higher Levels of Metalloproteinase Activity and Are More Aggressive In Vivo
title_sort acute lymphoid leukemia cells with greater stem cell antigen-1 (ly6a/sca-1) expression exhibit higher levels of metalloproteinase activity and are more aggressive in vivo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930640/
https://www.ncbi.nlm.nih.gov/pubmed/24586463
http://dx.doi.org/10.1371/journal.pone.0088966
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