Zonisamide Attenuates α-Synuclein Neurotoxicity by an Aggregation-Independent Mechanism in a Rat Model of Familial Parkinson’s Disease

The anti-epileptic agent zonisamide (ZNS) has been shown to exert protective effects in neurotoxin-based mouse models of Parkinson disease. However, it is unknown whether ZNS can attenuate toxicity of familial Parkinson’s disease-causing gene products. In this study, we investigated the effects of Z...

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Detalles Bibliográficos
Autores principales: Arawaka, Shigeki, Fukushima, Shingo, Sato, Hiroyasu, Sasaki, Asuka, Koga, Kaori, Koyama, Shingo, Kato, Takeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930669/
https://www.ncbi.nlm.nih.gov/pubmed/24586512
http://dx.doi.org/10.1371/journal.pone.0089076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930669/
https://www.ncbi.nlm.nih.gov/pubmed/24586512
http://dx.doi.org/10.1371/journal.pone.0089076

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