Cargando…

Small Molecule Inhibitors Target the Tissue Transglutaminase and Fibronectin Interaction

Tissue transglutaminase (TG2) mediates protein crosslinking through generation of ε−(γ-glutamyl) lysine isopeptide bonds and promotes cell adhesion through interaction with fibronectin (FN) and integrins. Cell adhesion to the peritoneal matrix regulated by TG2 facilitates ovarian cancer disseminatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yakubov, Bakhtiyor, Chen, Lan, Belkin, Alexey M., Zhang, Sheng, Chelladurai, Bhadrani, Zhang, Zhong-Yin, Matei, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930694/ https://www.ncbi.nlm.nih.gov/pubmed/24586660 http://dx.doi.org/10.1371/journal.pone.0089285

Ejemplares similares

Tissue Transglutaminase Is an Integrin-Binding Adhesion Coreceptor for Fibronectin
por: Akimov, Sergey S., et al.
Publicado: (2000)

Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer()()()
por: Lee, Jiyoon, et al.
Publicado: (2016)

The Outside-In Journey of Tissue Transglutaminase in Cancer
por: Sima, Livia Elena, et al.
Publicado: (2022)

Exercise, Vascular Stiffness, and Tissue Transglutaminase
por: Steppan, Jochen, et al.
Publicado: (2014)

Unconventional Secretion of Tissue Transglutaminase Involves Phospholipid-Dependent Delivery into Recycling Endosomes
por: Zemskov, Evgeny A., et al.
Publicado: (2011)

Astrocyte-Derived Tissue Transglutaminase Interacts with Fibronectin: A Role in Astrocyte Adhesion and Migration?
por: van Strien, Miriam E., et al.
Publicado: (2011)

PDGF induced microRNA alterations in cancer cells
por: Shao, Minghai, et al.
Publicado: (2011)

Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly
por: Zhong, Cuiling, et al.
Publicado: (1998)

Astrocyte-derived tissue Transglutaminase affects fibronectin deposition, but not aggregation, during cuprizone-induced demyelination
por: Espitia Pinzon, Nathaly, et al.
Publicado: (2017)

Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures
por: Espitia Pinzón, Nathaly, et al.
Publicado: (2017)

Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma
por: Yip, King Tuo, et al.
Publicado: (2016)

Intracellular Doppler Signatures of Platinum Sensitivity Captured by Biodynamic Profiling in Ovarian Xenografts
por: Merrill, Daniel, et al.
Publicado: (2016)

Tissue transglutaminase activates integrin-linked kinase and β-catenin in ovarian cancer
por: Condello, Salvatore, et al.
Publicado: (2022)

Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2)
por: Valdivia, Andres, et al.
Publicado: (2023)

Transglutaminase-2 Interaction with Heparin: IDENTIFICATION OF A HEPARIN BINDING SITE THAT REGULATES CELL ADHESION TO FIBRONECTIN-TRANSGLUTAMINASE-2 MATRIX
por: Lortat-Jacob, Hugues, et al.
Publicado: (2012)

A small molecule regulator of tissue transglutaminase conformation inhibits the malignant phenotype of cancer cells
por: Katt, William P., et al.
Publicado: (2018)

Abstract 173: 3D Transglutaminase Fibronectin Hydrogel For The Treatment Of Skin Wounds
por: Raghuram, Anjali C., et al.
Publicado: (2020)

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor
por: Wang, Zhuo, et al.
Publicado: (2018)

Transglutaminase 2: a novel therapeutic target for idiopathic pulmonary fibrosis using selective small molecule inhibitors
por: Fell, Shaun, et al.
Publicado: (2021)

3D Transglutaminase Fibronectin Hydrogel Therapy for Healing of Chronic Irradiated Porcine Skin Wounds
por: Raghuram, Anjali, et al.
Publicado: (2021)

Transcriptional activation and localization of expression of Brassica juncea putative metal transport protein BjMTP1
por: Muthukumar, Balasubramaniam, et al.
Publicado: (2007)

Tissue Transglutaminase but Not Microbial Transglutaminase Is Inhibited by Exogenous Oxidative Substances in Celiac Disease
por: Stricker, Sebastian, et al.
Publicado: (2022)

Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer
por: Sima, Livia Elena, et al.
Publicado: (2021)

5: 3D Transglutaminase Fibronectin Hydrogel Therapy Improves the Healing of Chronic Irradiated Porcine Skin Wounds
por: Raghuram, Anjali C., et al.
Publicado: (2021)

Tissue transglutaminase in the pathogenesis of heart failure
por: Shinde, Arti V., et al.
Publicado: (2017)

Transglutaminases Are Active in Perivascular Adipose Tissue
por: Orr, Alexis N., et al.
Publicado: (2021)

Role of tissue transglutaminase in the pathogenesis of diabetic cardiomyopathy and the intervention effect of rutin
por: GAO, HAI-CHENG, et al.
Publicado: (2015)

Transglutaminase 2—a novel inhibitor of adipogenesis
por: Myneni, V D, et al.
Publicado: (2015)

Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo
por: Jeitner, Thomas M., et al.
Publicado: (2018)

Mucosal tissue transglutaminase expression in celiac disease
por: Villanacci, Vincenzo, et al.
Publicado: (2009)

Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype
por: Gates, Eric W. J., et al.
Publicado: (2023)

Direct association of fibronectin and actin molecules in vitro
Publicado: (1980)

Metastasis suppressor NME1 regulates melanoma cell morphology, self‐adhesion and motility via induction of fibronectin expression
por: Novak, Marián, et al.
Publicado: (2015)

Induction of tissue transglutaminase in human peripheral blood monocytes
Publicado: (1984)

Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase
por: Liu, Chen, et al.
Publicado: (2017)

Tissue Transglutaminase Expression Associates With Progression of Multiple Sclerosis
por: Sestito, Claudia, et al.
Publicado: (2021)

Tissue transglutaminase treatment leads to concentration-dependent changes in dendritic cell phenotype - implications for the role of transglutaminase in coeliac disease
por: Dalleywater, William J, et al.
Publicado: (2012)

Prognostic value of transglutaminase 2 in non-small cell lung cancer patients
por: Chihong, Zhu, et al.
Publicado: (2017)

Correlation of Epididymal Protease Inhibitor and Fibronectin in Human Semen
por: Zhang, Xiangxiang, et al.
Publicado: (2013)

Majority of Children With Type 1 Diabetes Produce and Deposit Anti-Tissue Transglutaminase Antibodies in the Small Intestine
por: Maglio, Mariantonia, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_6ed0p8m1uats5rofvr87lpeb3d