Loss of Grainy Head-Like 1 Is Associated with Disruption of the Epidermal Barrier and Squamous Cell Carcinoma of the Skin

The Grainyhead-like 1 (GRHL1) transcription factor regulates the expression of desmosomal cadherin desmoglein 1 (Dsg1) in suprabasal layers of the epidermis. As a consequence, the epidermis of Grhl1-null mice displays fewer desmosomes that are abnormal in structure. These mice also exhibit mild chro...

Descripción completa

Detalles Bibliográficos
Autores principales: Mlacki, Michal, Darido, Charbel, Jane, Stephen M., Wilanowski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930704/
https://www.ncbi.nlm.nih.gov/pubmed/24586629
http://dx.doi.org/10.1371/journal.pone.0089247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930704/
https://www.ncbi.nlm.nih.gov/pubmed/24586629
http://dx.doi.org/10.1371/journal.pone.0089247

Ejemplares similares