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Optimization of a One-Step Heat-Inducible In Vivo Mini DNA Vector Production System
While safer than their viral counterparts, conventional circular covalently closed (CCC) plasmid DNA vectors offer a limited safety profile. They often result in the transfer of unwanted prokaryotic sequences, antibiotic resistance genes, and bacterial origins of replication that may lead to unwante...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930727/ https://www.ncbi.nlm.nih.gov/pubmed/24586704 http://dx.doi.org/10.1371/journal.pone.0089345 |