Disulfide Linkages in Plasmodium falciparum Plasmepsin-I Are Essential Elements for Its Processing Activity and Multi-Milligram Recombinant Production Yield

Plasmodium falciparum plasmepsin-I (PM-I) has been considered a potential drug target for the parasite that causes fatal malaria in human. Determination of PM-I structures for rational design of its inhibitors is hindered by the difficulty in obtaining large quantity of soluble enzyme. Nearly all at...

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Detalles Bibliográficos
Autores principales: Lolupiman, Sirisak, Siripurkpong, Pilaiwan, Yuvaniyama, Jirundon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930733/
https://www.ncbi.nlm.nih.gov/pubmed/24586769
http://dx.doi.org/10.1371/journal.pone.0089424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930733/
https://www.ncbi.nlm.nih.gov/pubmed/24586769
http://dx.doi.org/10.1371/journal.pone.0089424

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