Cargando…

Disulfide Linkages in Plasmodium falciparum Plasmepsin-I Are Essential Elements for Its Processing Activity and Multi-Milligram Recombinant Production Yield

Plasmodium falciparum plasmepsin-I (PM-I) has been considered a potential drug target for the parasite that causes fatal malaria in human. Determination of PM-I structures for rational design of its inhibitors is hindered by the difficulty in obtaining large quantity of soluble enzyme. Nearly all at...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lolupiman, Sirisak, Siripurkpong, Pilaiwan, Yuvaniyama, Jirundon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930733/ https://www.ncbi.nlm.nih.gov/pubmed/24586769 http://dx.doi.org/10.1371/journal.pone.0089424

Ejemplares similares

Essentiality of Plasmodium falciparum plasmepsin V
por: Boonyalai, Nonlawat, et al.
Publicado: (2018)

Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X
por: Li, Fengwu, et al.
Publicado: (2016)

Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
por: Inoue, Juliana, et al.
Publicado: (2018)

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine
por: Loesbanluechai, Duangkamon, et al.
Publicado: (2018)

Trafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum
por: Klemba, Michael, et al.
Publicado: (2004)

Assessment of Biological Role and Insight into Druggability of the Plasmodium falciparum Protease Plasmepsin V
por: Polino, Alexander J., et al.
Publicado: (2020)

In Silico and In Vitro Antimalarial Screening and Validation Targeting Plasmodium falciparum Plasmepsin V
por: Ji, Xin, et al.
Publicado: (2022)

The nepenthesin insert in the Plasmodium falciparum aspartic protease plasmepsin V is necessary for enzyme function
por: Polino, Alexander J., et al.
Publicado: (2022)

Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X
por: Mukherjee, Sumit, et al.
Publicado: (2022)

Bioprospection of Selected Plant Secondary Metabolites as Modulators of the Proteolytic Activity of Plasmodium falciparum Plasmepsin V
por: Sulyman, Abdulhakeem Olarewaju, et al.
Publicado: (2023)

Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors
por: Bedi, Rajiv K., et al.
Publicado: (2016)

Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
por: Bopp, Selina, et al.
Publicado: (2018)

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion
por: Triglia, Tony, et al.
Publicado: (2023)

A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance
por: Kane, John, et al.
Publicado: (2023)

Estradiol: micrograms or milligrams
por: Kirk, Jeremy M W, et al.
Publicado: (2016)

Enzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium berghei
por: Liu, Peng, et al.
Publicado: (2015)

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
por: Russo, Ilaria, et al.
Publicado: (2010)

Experimental Determination of the Membrane Topology of the Plasmodium Protease Plasmepsin V
por: Tarr, Sarah J., et al.
Publicado: (2015)

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity
por: Richardson, Lachlan W., et al.
Publicado: (2022)

DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum
por: Collins, Katharine A., et al.
Publicado: (2019)

Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum
por: Singh, Susheel K., et al.
Publicado: (2018)

African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker
por: Leroy, Didier, et al.
Publicado: (2019)

Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum
por: Ansbro, Megan R., et al.
Publicado: (2020)

No evidence of amplified Plasmodium falciparum plasmepsin II gene copy number in an area with artemisinin-resistant malaria along the China–Myanmar border
por: Huang, Fang, et al.
Publicado: (2020)

Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?
por: Foguim Tsombeng, Francis, et al.
Publicado: (2019)

Plasmepsin-like Aspartyl Proteases in Babesia
por: Šnebergerová, Pavla, et al.
Publicado: (2021)

Reductive aminations by imine reductases: from milligrams to tons
por: Gilio, Amelia K., et al.
Publicado: (2022)

Activation of the Plasmodium Egress Effector Subtilisin-Like Protease 1 Is Mediated by Plasmepsin X Destruction of the Prodomain
por: Mukherjee, Sumit, et al.
Publicado: (2023)

Milligram Quantities of Homogeneous Recombinant Full-Length Mouse Munc18c from Escherichia coli Cultures
por: Rehman, Asma, et al.
Publicado: (2013)

Recombination Hotspots and Population Structure in Plasmodium falciparum
por: Mu, Jianbing, et al.
Publicado: (2005)

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion
por: Nasamu, Armiyaw S., et al.
Publicado: (2017)

Systematic Exploration of SARS-CoV-2 Adaptation to Vero E6, Vero E6/TMPRSS2, and Calu-3 Cells
por: Aiewsakun, Pakorn, et al.
Publicado: (2023)

Plasmepsin V, a Secret Weapon Against Malaria
por: Sedwick, Caitlin
Publicado: (2014)

Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents
por: Mueller, Reto, et al.
Publicado: (2003)

Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype
por: Spaccapelo, Roberta, et al.
Publicado: (2011)

A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using ÄKTAxpress(TM)
por: Nowicki, Matthew W., et al.
Publicado: (2015)

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region
por: Gambini, Luca, et al.
Publicado: (2015)

In silico discovery of transcription regulatory elements in Plasmodium falciparum
por: Young, Jason A, et al.
Publicado: (2008)

Genetic Determination and Linkage Mapping of Plasmodium falciparum Malaria Related Traits in Senegal
por: Sakuntabhai, Anavaj, et al.
Publicado: (2008)

Milligram Production and Biological Activity Characterization of the Human Chemokine Receptor CCR3
por: Wang, Mingqing, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_k61ugaed15escb8mid76f346dt