Mutation or Loss of p53 Differentially Modifies TGFβ Action in Ovarian Cancer

Ovarian cancer is the most lethal gynecological disease affecting women in the US. The Cancer Genome Atlas Network identified p53 mutations in 96% of high-grade serous ovarian carcinomas, demonstrating its critical role. Additionally, the Transforming Growth Factor Beta (TGFβ) pathway is dysfunction...

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Detalles Bibliográficos
Autores principales: Ó hAinmhire, Eoghainín, Quartuccio, Suzanne M., Cheng, Whay, Ahmed, Roshan A., King, Shelby M., Burdette, Joanna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930740/
https://www.ncbi.nlm.nih.gov/pubmed/24586866
http://dx.doi.org/10.1371/journal.pone.0089553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930740/
https://www.ncbi.nlm.nih.gov/pubmed/24586866
http://dx.doi.org/10.1371/journal.pone.0089553

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