Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth

BACKGROUND: Recent genome-wide studies have shown that approximately 30% of diffuse large B-cell lymphoma (DLBCL) cases harbor mutations in the histone acetyltransferase (HAT) coactivators p300 or CBP. The majority of these mutations reduce or eliminate the catalytic HAT activity. We previously demo...

Descripción completa

Detalles Bibliográficos
Autores principales: Haery, Leila, Lugo-Picó, Julián G, Henry, Ryan A, Andrews, Andrew J, Gilmore, Thomas D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930761/
https://www.ncbi.nlm.nih.gov/pubmed/24529102
http://dx.doi.org/10.1186/1476-4598-13-29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930761/
https://www.ncbi.nlm.nih.gov/pubmed/24529102
http://dx.doi.org/10.1186/1476-4598-13-29

Ejemplares similares