Decrease of UPR- and ERAD-related proteins in Pichia pastoris during methanol-induced secretory insulin precursor production in controlled fed-batch cultures

BACKGROUND: Pichia pastoris is a popular yeast preferably employed for secretory protein production. Secretion is not always efficient and endoplasmic retention of proteins with aberrant folding properties, or when produced at exaggerated rates, can occur. In these cases production usually leads to...

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Detalles Bibliográficos
Autores principales: Vanz, Ana Letícia, Nimtz, Manfred, Rinas, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930904/
https://www.ncbi.nlm.nih.gov/pubmed/24521445
http://dx.doi.org/10.1186/1475-2859-13-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930904/
https://www.ncbi.nlm.nih.gov/pubmed/24521445
http://dx.doi.org/10.1186/1475-2859-13-23

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