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Proximity of TCR and its CD8 coreceptor controls sensitivity of T cells()

Spatial organisation of T cell receptor (TCR) and its coreceptor CD8 on the surface of live naïve and Ag-experienced CD8(+) T cells was resolved by fluorescence lifetime cross-correlation microscopy. We found that exposure of naïve CD8(+) T cells to antigen (Ag) causes formation of [TCR, CD8] functi...

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Detalles Bibliográficos
Autores principales:	Borger, Jessica G., Zamoyska, Rose, Gakamsky, Dmitry M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier/North-Holland Biomedical Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931270/ https://www.ncbi.nlm.nih.gov/pubmed/24263053 http://dx.doi.org/10.1016/j.imlet.2013.11.005

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